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Possible new applications of aluminium adjuvants in, for example, combined aluminium-adsorbed protein and DNA oligonucleotide vaccines as well as the possible use of aluminium adjuvants in combination with IL-12 to stimulate Th1-type immune responses are mentioned.

Adjuvant Department, Brenntag Biosector, DK-3600 Frederikssund, Denmark Correspondence: Dr EB Lindblad, Adjuvant Department, Brenntag Biosector, DK-3600 Frederikssund, Denmark.

Email: [email protected] ; Accepted 5 July 2004.

Aluminium adjuvants are the most widely used adjuvants in both human and veterinary vaccines.

These adjuvants have been used in practical vaccination for more than 60 years and are generally recognized as safe and as stimulators of Th2 immunity.

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